James William Charles Pennington (c. 1807 – October 22, 1870) was an American abolitionist, orator, minister and writer active in Brooklyn, New York. He escaped at the age of 19 from slavery in western Maryland and reached New York. After working in Brooklyn and gaining some education, he was the first African American allowed to attend classes at Yale University, though he was not allowed to formally enroll. He was ordained as a minister in the Congregational Church, later also serving in Presbyterian churches for congregations in Hartford, Connecticut; and New York. After the Civil War, he served congregations in Natchez, Mississippi; Portland, Maine; and Jacksonville, Florida.

In the Antebellum period, Pennington was an abolitionist, and among the American delegates to the Second World Conference on Slavery in London. In 1850, he happened to be in Scotland when the Fugitive Slave Act was passed by the US Congress. As it increased the risk for fugitive slaves in the North, Pennington stayed in the British Isles while friends worked to buy his freedom from his former master and then from his estate. Pennington raised funds for the abolition movement on the public lecture circuit in England.

Pennington wrote and published what is considered the first history of blacks in the United States, The Origin and History of the Colored People (1841). His memoir, The Fugitive Blacksmith, was first published in 1849 in London.